1,2-Dichloroethane → 1'-(1,4-dioxaspiro[4.5]decan-8-yl)spiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1H)-one

HRID 1214842Notes

Reaction equation

HRID 1214842 reaction equation
[C:32]([O:33][BH-:34]([O:35][C:36](=[O:37])[CH3:38])[O:39][C:40](=[O:41])[CH3:42])(=[O:43])[CH3:44].[CH2:17]1[CH2:18][O:19][C:20]2([CH2:21][CH2:22][C:23](=[O:26])[CH2:24][CH2:25]2)[O:27]1.[CH3:28][C:29](=[O:30])[OH:31].[Cl:46][CH2:47][CH2:48][Cl:49].[NH:1]1[CH2:2][CH2:3][C:4]2([c:5]3[c:6]([cH:11][cH:12][cH:13][cH:14]3)[NH:7][C:8](=[O:10])[O:9]2)[CH2:15][CH2:16]1.[Na+:45]>>[N:1]1([CH:23]2[CH2:22][CH2:21][C:20]3([O:19][CH2:18][CH2:17][O:27]3)[CH2:25][CH2:24]2)[CH2:2][CH2:3][C:4]2([c:5]3[c:6]([cH:11][cH:12][cH:13][cH:14]3)[NH:7][C:8](=[O:10])[O:9]2)[CH2:15][CH2:16]1

Participants

7

Reactant 6

HCID 111,2-DichloroethaneHCID 176Acetic AcidHCID 923Sodium ionHCID 5674151,4-Dioxaspiro[4.5]decan-8-oneHCID 2724942TriacetoxyborohydrideHCID 13050639Spiro[3,1-benzoxazine-4,4'-piperidin]-2(1H)-one

Product 1

HCID 250609581'-(1,4-dioxaspiro[4.5]decan-8-yl)spiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1H)-one

Sources & evidence

ORD record
ord-e11d4283eb4145459b4c9b10f6596a30
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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