Dichloromethane → tert-butyl N-[[3-[7-fluoro-1-(2-fluoroethyl)-2-oxo-3H-indol-5-yl]-2-oxo-1,3-oxazolidin-5-yl]methyl]carbamate

HRID 1215026Notes

Reaction equation

HRID 1215026 reaction equation
[C:5]([CH3:6])([CH3:7])([CH3:8])[O:9][C:10]([NH:11][CH2:12][CH:13]([CH2:14][NH:15][c:16]1[cH:17][c:18]2[c:22]([c:23]([F:25])[cH:24]1)[N:21]([CH2:26][CH2:27][F:28])[C:20](=[O:29])[CH2:19]2)[OH:30])=[O:31].[CH3:32][CH2:33][N:34]([CH2:35][CH3:36])[CH2:37][CH3:38].[Cl:1][C:2]([Cl:3])=[O:4].[Cl:39][CH2:40][Cl:41]>>[C:2]1(=[O:4])[N:15]([c:16]2[cH:17][c:18]3[c:22]([c:23]([F:25])[cH:24]2)[N:21]([CH2:26][CH2:27][F:28])[C:20](=[O:29])[CH2:19]3)[CH2:14][CH:13]([CH2:12][NH:11][C:10]([O:9][C:5]([CH3:6])([CH3:7])[CH3:8])=[O:31])[O:30]1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 6371PhosgeneHCID 8471TriethylamineHCID 87761855tert-butyl N-[3-[[7-fluoro-1-(2-fluoroethyl)-2-oxo-3H-indol-5-yl]amino]-2-hydroxypropyl]carbamate

Product 1

HCID 87761836tert-butyl N-[[3-[7-fluoro-1-(2-fluoroethyl)-2-oxo-3H-indol-5-yl]-2-oxo-1,3-oxazolidin-5-yl]methyl]carbamate

Sources & evidence

ORD record
ord-b97aa923d1e34f678174f35d9025ed36
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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