Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1215235Generated: November 2, 2026

Dichloromethane → rac-(2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2-methoxycarbonyl-2-methyl-propyl)-pyrrolidine-2-carboxylic acid tert-butyl ester

https://huagongshe.com/reaction/1215235

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDichloromethaneHCID 6344—
Reactanttert-ButanolHCID 6386—
ReactantTriethylamineHCID 8471—
Reactant1,8-Diazabicyclo(5.4.0)undec-7-eneHCID 81184—
Reactant4-[(E)-tert-butoxycarbonylmethylimino]-2,2-dimethyl-butyric acid methyl esterHCID 59249412—
ReactantC15H7Cl2F2NHCID 66665986—
Productrac-(2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2-methoxycarbonyl-2-methyl-propyl)-pyrrolidine-2-carboxylic acid tert-butyl esterHCID 66666249—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetTraining data from https://doi.org/10.1039/C8SC04228D (5/10)
ORD IDord-7efa8a685ffd4ee4a7441eaa8f9e0c35
Source noteTraining data from https://doi.org/10.1039/C8SC04228D (5/10)