Dichloromethane → rac-(2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2-methoxycarbonyl-2-methyl-propyl)-pyrrolidine-2-carboxylic acid tert-butyl ester
Reaction equation
[CH2:46]1[CH2:47][CH2:48][C:49]2=[N:54][CH2:53][CH2:52][CH2:51][N:50]2[CH2:55][CH2:56]1.[CH3:1][O:2][C:3]([C:4]([CH2:5][CH:6]=[N:7][CH2:8][C:9](=[O:10])[O:11][C:12]([CH3:13])([CH3:14])[CH3:15])([CH3:16])[CH3:17])=[O:18].[CH3:39][CH2:40][N:41]([CH2:42][CH3:43])[CH2:44][CH3:45].[CH3:60][C:61]([OH:62])([CH3:63])[CH3:64].[Cl:19][c:20]1[c:21]([F:38])[c:22]([CH:26]=[C:27]([C:28]#[N:29])[c:30]2[c:31]([F:37])[cH:32][c:33]([Cl:36])[cH:34][cH:35]2)[cH:23][cH:24][cH:25]1.[Cl:57][CH2:58][Cl:59]>>[CH3:1][O:2][C:3]([C:4]([CH2:5][CH:6]1[NH:7][CH:8]([C:9](=[O:10])[O:11][C:12]([CH3:13])([CH3:14])[CH3:15])[CH:26]([c:22]2[c:21]([F:38])[c:20]([Cl:19])[cH:25][cH:24][cH:23]2)[C:27]1([C:28]#[N:29])[c:30]1[c:31]([F:37])[cH:32][c:33]([Cl:36])[cH:34][cH:35]1)([CH3:16])[CH3:17])=[O:18]Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-7efa8a685ffd4ee4a7441eaa8f9e0c35
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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