Dichloromethane → 7-[3-(4-acetylpiperazin-1-yl)propoxy]-4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxyquinazoline
Reaction equation
[C:26]([CH3:27])(=[O:28])[N:29]1[CH2:30][CH2:31][N:32]([CH2:35][CH2:36][CH2:37][OH:38])[CH2:33][CH2:34]1.[CH2:72]([Cl:73])[Cl:74].[F:1][c:2]1[c:3]2[cH:4][c:5]([CH3:25])[nH:6][c:7]2[cH:8][cH:9][c:10]1[O:11][c:12]1[n:13][cH:14][n:15][c:16]2[cH:17][c:18]([OH:24])[c:19]([O:22][CH3:23])[cH:20][c:21]12.[O:58]=[C:59]([O:60][CH:61]([CH3:62])[CH3:63])[N:64]=[N:65][C:66]([O:67][CH:68]([CH3:69])[CH3:70])=[O:71].[c:39]1([P:40]([c:41]2[cH:42][cH:43][cH:44][cH:45][cH:46]2)[c:47]2[cH:48][cH:49][cH:50][cH:51][cH:52]2)[cH:53][cH:54][cH:55][cH:56][cH:57]1>>[F:1][c:2]1[c:3]2[cH:4][c:5]([CH3:25])[nH:6][c:7]2[cH:8][cH:9][c:10]1[O:11][c:12]1[n:13][cH:14][n:15][c:16]2[cH:17][c:18]([O:24][CH2:37][CH2:36][CH2:35][N:32]3[CH2:31][CH2:30][N:29]([C:26]([CH3:27])=[O:28])[CH2:34][CH2:33]3)[c:19]([O:22][CH3:23])[cH:20][c:21]12Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-e98f499c326e4e6db4121c4f51d49986
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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