Acetic Acid → 2-(2-Amino-4-chloro-6-fluoro-3-hydroxyphenyl)-3-chloro-5-trifluoromethylpyridine

HRID 121554Notes

Reaction equation

HRID 121554 reaction equation
[CH3:24][C:25](=[O:26])[OH:27].[CH3:28][OH:29].[Cl:1][c:2]1[cH:3][c:4]([F:23])[c:5](-[c:12]2[n:13][cH:14][c:15]([C:19]([F:20])([F:21])[F:22])[cH:16][c:17]2[Cl:18])[c:6]([N+:9]([O-:10])=[O:11])[c:7]1[OH:8].[Fe:30]>>[Cl:1][c:2]1[cH:3][c:4]([F:23])[c:5](-[c:12]2[n:13][cH:14][c:15]([C:19]([F:20])([F:21])[F:22])[cH:16][c:17]2[Cl:18])[c:6]([NH2:9])[c:7]1[OH:8]

Participants

5

Reactant 4

HCID 176Acetic AcidHCID 887MethanolHCID 23925IronHCID 224661452-(4-Chloro-2-fluoro-5-hydroxy-6-nitrophenyl)-3-chloro-5-trifluoromethylpyridine

Product 1

HCID 224661462-(2-Amino-4-chloro-6-fluoro-3-hydroxyphenyl)-3-chloro-5-trifluoromethylpyridine

Sources & evidence

ORD record
ord-8dff7d181fd642b1b0ed7a39d14b0c53
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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