Chloroform → 1-(Pyridin-4-yl)-4-(1,2,3,4-tetrahydroisoquinolin-7-yloxymethyl)piperidine-4-carboxylic acid ethyl ester

HRID 1215879Notes

Reaction equation

HRID 1215879 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][c:10]2[cH:11][c:12]([O:18][CH2:19][C:20]3([C:32](=[O:33])[O:34][CH2:35][CH3:36])[CH2:21][CH2:22][N:23]([c:26]4[cH:27][cH:28][n:29][cH:30][cH:31]4)[CH2:24][CH2:25]3)[cH:13][cH:14][c:15]2[CH2:16][CH2:17]1)([CH3:5])([CH3:6])[CH3:7].[CH:44]([Cl:45])([Cl:46])[Cl:47].[OH:37][C:38]([C:39]([F:40])([F:41])[F:42])=[O:43]>>[NH:8]1[CH2:9][c:10]2[cH:11][c:12]([O:18][CH2:19][C:20]3([C:32](=[O:33])[O:34][CH2:35][CH3:36])[CH2:21][CH2:22][N:23]([c:26]4[cH:27][cH:28][n:29][cH:30][cH:31]4)[CH2:24][CH2:25]3)[cH:13][cH:14][c:15]2[CH2:16][CH2:17]1

Participants

4

Reactant 3

HCID 6212ChloroformHCID 6422Trifluoroacetic acidHCID 600641857-[4-Ethoxycarbonyl-1-(pyridin-4-yl)piperidin-4-ylmethoxy]-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid tert-butyl ester

Product 1

HCID 600641381-(Pyridin-4-yl)-4-(1,2,3,4-tetrahydroisoquinolin-7-yloxymethyl)piperidine-4-carboxylic acid ethyl ester

Sources & evidence

ORD record
ord-cceffd457eb347819c2fed305740b00b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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