1,4-Dibromobenzene → 1-Boc-4-(4-bromo-phenyl)-piperidin-4-ol

HRID 1216029Notes

Reaction equation

HRID 1216029 reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5]([Br:6])[cH:7][cH:8]1.[C:14](=[O:15])([O:16][C:17]([CH3:18])([CH3:19])[CH3:20])[N:21]1[CH2:22][CH2:23][C:24](=[O:27])[CH2:25][CH2:26]1.[CH2:28]1[O:29][CH2:30][CH2:31][CH2:32]1.[CH3:9][CH2:10][CH2:11][CH2:12][Li:13]>>[c:2]1([C:24]2([OH:27])[CH2:23][CH2:22][N:21]([C:14](=[O:15])[O:16][C:17]([CH3:18])([CH3:19])[CH3:20])[CH2:26][CH2:25]2)[cH:3][cH:4][c:5]([Br:6])[cH:7][cH:8]1

Participants

5

Reactant 4

HCID 78041,4-DibromobenzeneHCID 8028TetrahydrofuranHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylateHCID 178418339Butyllithium

Product 1

HCID 183795571-Boc-4-(4-bromo-phenyl)-piperidin-4-ol

Sources & evidence

ORD record
ord-3ce173a785764492bea6a417b383ee00
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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