Bromide ion → 7-(4-Fluoro-benzyl)-6-hydroxy-5-methoxy-6-methyl-9-triisopropylsilanyloxy-6,7-dihydro-pyrrolo[3,4-g]quinolin-8-one

HRID 1216111Notes

Reaction equation

HRID 1216111 reaction equation
[Br-:37].[CH2:40]1[O:41][CH2:42][CH2:43][CH2:44]1.[CH3:38][Mg+:39].[F:1][c:2]1[cH:3][cH:4][c:5]([CH2:6][N:7]2[C:8](=[O:34])[c:9]3[c:10]([O:32][CH3:33])[c:11]4[cH:12][cH:13][cH:14][n:15][c:16]4[c:17]([O:21][Si:22]([CH:23]([CH3:24])[CH3:25])([CH:26]([CH3:27])[CH3:28])[CH:29]([CH3:30])[CH3:31])[c:18]3[C:19]2=[O:20])[cH:35][cH:36]1>>[F:1][c:2]1[cH:3][cH:4][c:5]([CH2:6][N:7]2[C:8]([OH:34])([CH3:38])[c:9]3[c:10]([O:32][CH3:33])[c:11]4[cH:12][cH:13][cH:14][n:15][c:16]4[c:17]([O:21][Si:22]([CH:23]([CH3:24])[CH3:25])([CH:26]([CH3:27])[CH3:28])[CH:29]([CH3:30])[CH3:31])[c:18]3[C:19]2=[O:20])[cH:35][cH:36]1

Participants

5

Reactant 4

HCID 259Bromide ionHCID 8028TetrahydrofuranHCID 58928738HCID 58928738, compoundHCID 178477777HCID 178477777, compound

Product 1

HCID 589289857-(4-Fluoro-benzyl)-6-hydroxy-5-methoxy-6-methyl-9-triisopropylsilanyloxy-6,7-dihydro-pyrrolo[3,4-g]quinolin-8-one

Sources & evidence

ORD record
ord-cdfb7913b0fc4f7281d81b8404a0107e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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