Dimethylformamide → 5-Bromo-4-chloro-2-ethyl-1-(2,2,2-trifluoroethyl)-1H-benzimidazole

HRID 1216544Notes

Reaction equation

HRID 1216544 reaction equation
[Br:1][c:2]1[c:3]([Cl:13])[c:4]2[c:5]([nH:6][c:7]([CH2:9][CH3:10])[n:8]2)[cH:11][cH:12]1.[C:27](=[O:28])([O-:29])[O-:30].[Cs+:31].[Cs+:32].[O:33]=[CH:34][N:35]([CH3:36])[CH3:37].[S:14]([O:15][CH2:22][C:23]([F:24])([F:25])[F:26])([C:16]([F:17])([F:18])[F:19])(=[O:20])=[O:21]>>[Br:1][c:2]1[c:3]([Cl:13])[c:4]2[c:5]([n:6]([CH2:22][C:23]([F:24])([F:25])[F:26])[c:7]([CH2:9][CH3:10])[n:8]2)[cH:11][cH:12]1

Participants

6

Reactant 5

HCID 6228DimethylformamideHCID 19660Carbonate IonHCID 803662,2,2-Trifluoroethyl trifluoromethanesulfonateHCID 104967Cesium cation2×HCID 578001585-bromo-4-chloro-2-ethyl-1H-benzimidazole

Product 1

HCID 578001385-Bromo-4-chloro-2-ethyl-1-(2,2,2-trifluoroethyl)-1H-benzimidazole

Sources & evidence

ORD record
ord-b6312d6359bc4910b20a7a23d2fe25b3
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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