Tetrahydrofuran → 2-(4-(1,3-Dioxan-2-yl)-2-fluorophenyl)-5-(1-(3,3-difluoro-cyclobutyl)vinyl)thiazolo[5,4-b]pyridine

HRID 1217629Notes

Reaction equation

HRID 1217629 reaction equation
[CH2:37]1[O:38][CH2:39][CH2:40][CH2:41]1.[KH:36].[O:1]1[CH:2]([c:7]2[cH:8][c:9]([F:35])[c:10](-[c:13]3[s:14][c:15]4[n:16][c:17]([C:22]([CH2:23][Si:25]([CH3:26])([CH3:27])[CH3:28])([OH:24])[CH:29]5[CH2:30][C:31]([F:33])([F:34])[CH2:32]5)[cH:18][cH:19][c:20]4[n:21]3)[cH:11][cH:12]2)[O:3][CH2:4][CH2:5][CH2:6]1>>[O:1]1[CH:2]([c:7]2[cH:8][c:9]([F:35])[c:10](-[c:13]3[s:14][c:15]4[n:16][c:17]([C:22](=[CH2:23])[CH:29]5[CH2:30][C:31]([F:33])([F:34])[CH2:32]5)[cH:18][cH:19][c:20]4[n:21]3)[cH:11][cH:12]2)[O:3][CH2:4][CH2:5][CH2:6]1

Participants

4

Reactant 3

HCID 8028TetrahydrofuranHCID 671117021-(2-(4-(1,3-Dioxan-2-yl)-2-fluorophenyl)thiazolo[5,4-b]pyridin-5-yl)-1-(3,3-difluorocyclobutyl)-2-(trimethylsilyl)ethanolHCID 178506623HCID 178506623, compound

Product 1

HCID 671119192-(4-(1,3-Dioxan-2-yl)-2-fluorophenyl)-5-(1-(3,3-difluoro-cyclobutyl)vinyl)thiazolo[5,4-b]pyridine

Sources & evidence

ORD record
ord-7e573ba9b74c46f0974f101b26f29bf2
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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