Trifluoroacetic acid → (RS)-4-[3-(4-Hydroxy-benzenesulfonyl)-pyrrolidin-1-yl]-piperidine-1-carboxylic acid tert-butyl ester

HRID 1217640Notes

Reaction equation

HRID 1217640 reaction equation
[C:23]([CH3:24])([CH3:25])([CH3:26])[O:27][C:28](=[O:29])[N:30]1[CH2:31][CH2:32][C:33](=[O:36])[CH2:34][CH2:35]1.[F:1][C:2]([F:3])([F:4])[C:5]([OH:6])=[O:7].[NH:8]1[CH2:9][CH:10]([S:13](=[O:14])(=[O:15])[c:16]2[cH:17][cH:18][c:19]([OH:22])[cH:20][cH:21]2)[CH2:11][CH2:12]1>>[N:8]1([CH:33]2[CH2:32][CH2:31][N:30]([C:28]([O:27][C:23]([CH3:24])([CH3:25])[CH3:26])=[O:29])[CH2:35][CH2:34]2)[CH2:9][CH:10]([S:13](=[O:14])(=[O:15])[c:16]2[cH:17][cH:18][c:19]([OH:22])[cH:20][cH:21]2)[CH2:11][CH2:12]1

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylateHCID 184257724-Pyrrolidin-3-ylsulfonylphenol

Product 1

HCID 69926062(RS)-4-[3-(4-Hydroxy-benzenesulfonyl)-pyrrolidin-1-yl]-piperidine-1-carboxylic acid tert-butyl ester

Sources & evidence

ORD record
ord-c3ebfb0072cb4150a2463c34b2a51d60
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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