Dichloromethane → 2-Oxo-1-phenyl-1,2,5,6,7,8-hexahydro-1,6-naphthyridine-3-carbonitrile

HRID 121769Notes

Reaction equation

HRID 121769 reaction equation
[C:1](#[N:2])[c:3]1[c:4](=[O:26])[n:5](-[c:20]2[cH:21][cH:22][cH:23][cH:24][cH:25]2)[c:6]2[c:11]([cH:12]1)[CH2:10][N:9]([C:13]([O:14][C:15]([CH3:16])([CH3:17])[CH3:18])=[O:19])[CH2:8][CH2:7]2.[Cl:27][CH2:28][Cl:29].[F:30][C:31]([F:32])([F:33])[C:34]([OH:35])=[O:36]>>[C:1](#[N:2])[c:3]1[c:4](=[O:26])[n:5](-[c:20]2[cH:21][cH:22][cH:23][cH:24][cH:25]2)[c:6]2[c:11]([cH:12]1)[CH2:10][NH:9][CH2:8][CH2:7]2

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 58026066tert-butyl 3-cyano-2-oxo-1-phenyl-1,2,7,8-tetrahydro-1,6-naphthyridine-6(5H)-carboxylate

Product 1

HCID 580260402-Oxo-1-phenyl-1,2,5,6,7,8-hexahydro-1,6-naphthyridine-3-carbonitrile

Sources & evidence

ORD record
ord-ef87db266476445f995bddb68959fefb
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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