Pyridine → 2-Cyclohexylthiazole-4-carboxylic acid (6-acetyl-3-methoxy-2-methylphenyl)amide

HRID 1217741Notes

Reaction equation

HRID 1217741 reaction equation
[C:20]([CH3:21])(=[O:22])[c:23]1[c:24]([NH2:25])[c:26]([CH3:32])[c:27]([O:30][CH3:31])[cH:28][cH:29]1.[CH:6]1([c:12]2[s:13][cH:14][c:15]([C:17](=[O:18])[OH:19])[n:16]2)[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11]1.[P:1]([Cl:2])([Cl:3])([Cl:4])=[O:5].[cH:33]1[cH:34][cH:35][n:36][cH:37][cH:38]1>>[CH:6]1([c:12]2[s:13][cH:14][c:15]([C:17](=[O:19])[NH:25][c:24]3[c:23]([C:20]([CH3:21])=[O:22])[cH:29][cH:28][c:27]([O:30][CH3:31])[c:26]3[CH3:32])[n:16]2)[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11]1

Participants

5

Reactant 4

HCID 1049PyridineHCID 24813Phosphorus oxychlorideHCID 234049342-Cyclohexyl-1,3-thiazole-4-carboxylic acidHCID 250673162'-Amino-3'-methyl-4'-methoxyacetophenone

Product 1

HCID 579564522-Cyclohexylthiazole-4-carboxylic acid (6-acetyl-3-methoxy-2-methylphenyl)amide

Sources & evidence

ORD record
ord-9c7eb965bce5443798a180a2476e9c96
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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