Bicarbonate Ion → 4-Chloro-2-(5-chloro-2-fluorophenyl)-5,6,7,8-tetrahydroquinazoline

HRID 1217835Notes

Reaction equation

HRID 1217835 reaction equation
[CH2:30]([Cl:31])[Cl:32].[Cl:1][c:2]1[cH:3][cH:4][c:5]([F:19])[c:6](-[c:8]2[n:9][c:10]3[c:15]([c:16]([OH:18])[n:17]2)[CH2:14][CH2:13][CH2:12][CH2:11]3)[cH:7]1.[Na+:24].[O-:20][C:21]([OH:22])=[O:23].[P:25]([Cl:26])([Cl:27])([Cl:28])=[O:29]>>[Cl:1][c:2]1[cH:3][cH:4][c:5]([F:19])[c:6](-[c:8]2[n:9][c:10]3[c:15]([c:16]([Cl:27])[n:17]2)[CH2:14][CH2:13][CH2:12][CH2:11]3)[cH:7]1

Participants

6

Reactant 5

HCID 769Bicarbonate IonHCID 923Sodium ionHCID 6344DichloromethaneHCID 24813Phosphorus oxychlorideHCID 178517509HCID 178517509, compound

Product 1

HCID 211043374-Chloro-2-(5-chloro-2-fluorophenyl)-5,6,7,8-tetrahydroquinazoline

Sources & evidence

ORD record
ord-ee95206822de4fdba51778064a0245e9
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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