反应详情

温度

80 °C

6-chloro-7-methoxy-9H-β-carbolin-8-ylamine (100 mg, 0.4 mmol), EDCI (125 mg, 0.64 mmol) and 2-methyl nicotinic acid (66 mg, 0.48 mmol) were taken in a round-bottom flask and suspended in pyridine (2 ml). The resulting mixture was heated at 80° C. overnight. The pyridine was then removed by rotary evaporation and 5% Na2CO3 solution was added. The resulting solid that precipitated out was collected by filtration. Chromatographic purification gave the desired product in 50-70% yield.

1. customThe pyridine was then removed by rotary evaporation and 5% Na2CO3 solution
2. additionwas added
3. customThe resulting solid that precipitated out
4. filtrationwas collected by filtration
5. customChromatographic purification