Acetonitrile → 2-[2-[(4-chlorophenyl)methyl]-1,2,4-triazol-3-yl]-N-[7-(trifluoromethyl)-3,4-dihydro-2H-chromen-4-yl]pyrrolidine-1-carboxamide

HRID 1218175Notes

Reaction equation

HRID 1218175 reaction equation
[CH3:46][C:47]#[N:48].[CH:37]([N:38]([CH2:39][CH3:40])[CH:41]([CH3:42])[CH3:43])([CH3:44])[CH3:45].[Cl:1][c:2]1[cH:3][cH:4][c:5]([CH2:6][n:7]2[n:8][cH:9][n:10][c:11]2[CH:12]2[N:13]([C:17](=[O:18])[Cl:19])[CH2:14][CH2:15][CH2:16]2)[cH:20][cH:21]1.[NH2:22][CH:23]1[CH2:24][CH2:25][O:26][c:27]2[cH:28][c:29]([C:33]([F:34])([F:35])[F:36])[cH:30][cH:31][c:32]21>>[Cl:1][c:2]1[cH:3][cH:4][c:5]([CH2:6][n:7]2[n:8][cH:9][n:10][c:11]2[CH:12]2[N:13]([C:17](=[O:18])[NH:22][CH:23]3[CH2:24][CH2:25][O:26][c:27]4[cH:28][c:29]([C:33]([F:34])([F:35])[F:36])[cH:30][cH:31][c:32]43)[CH2:14][CH2:15][CH2:16]2)[cH:20][cH:21]1

Participants

5

Reactant 4

HCID 6342AcetonitrileHCID 81531DiisopropylethylamineHCID 468354217-(Trifluoromethyl)chroman-4-amineHCID 765829282-[2-[(4-Chlorophenyl)methyl]-1,2,4-triazol-3-yl]pyrrolidine-1-carbonyl chloride

Product 1

HCID 688117462-[2-[(4-chlorophenyl)methyl]-1,2,4-triazol-3-yl]-N-[7-(trifluoromethyl)-3,4-dihydro-2H-chromen-4-yl]pyrrolidine-1-carboxamide

Sources & evidence

ORD record
ord-b231dc119b4e46d69e259f855d280b46
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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