Dichloromethane → 2-(1-Ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-4-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester

HRID 1218302Notes

Reaction equation

HRID 1218302 reaction equation
[C:45](=[O:46])([O:47][C:48]([CH3:49])([CH3:50])[CH3:51])[N:52]1[CH:53]([C:54](=[O:55])[OH:56])[CH2:57][CH:58]([OH:59])[CH2:60]1.[CH2:34]([CH3:35])[O:36][C:37](=[O:38])[C:39]1([NH2:44])[CH:40]([CH:42]=[CH2:43])[CH2:41]1.[CH:25]([N:26]([CH:27]([CH3:28])[CH3:29])[CH2:30][CH3:31])([CH3:32])[CH3:33].[Cl:61][CH2:62][Cl:63].[P-:1]([F:2])([F:3])([F:4])([F:5])([F:6])[F:7].[n:8]1([O:9][C:10]([N:11]([CH3:12])[CH3:13])=[N+:14]([CH3:15])[CH3:16])[c:17]2[n:18][cH:19][cH:20][cH:21][c:22]2[n:23][n:24]1>>[CH2:34]([CH3:35])[O:36][C:37](=[O:38])[C:39]1([NH:44][C:54]([CH:53]2[N:52]([C:45](=[O:46])[O:47][C:48]([CH3:49])([CH3:50])[CH3:51])[CH2:60][CH:58]([OH:59])[CH2:57]2)=[O:55])[CH:40]([CH:42]=[CH2:43])[CH2:41]1

Participants

7

Reactant 6

HCID 6344DichloromethaneHCID 9886HexafluorophosphateHCID 81531DiisopropylethylamineHCID 3352551-((Tert-butoxy)carbonyl)-4-hydroxypyrrolidine-2-carboxylic acidHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 22082824Ethyl 1-amino-2-vinylcyclopropanecarboxylate

Product 1

HCID 235716032-(1-Ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-4-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester

Sources & evidence

ORD record
ord-595dac3059b142d3baaf88beaca4c813
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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