Tetrahydrofuran → 4-((1-(benzyloxymethyl)-1H-benzo[d]imidazol-2-yl)(5-ethoxy-2-fluoro-3-isopropoxyphenyl)methylamino)benzonitrile

HRID 121841Notes

Reaction equation

HRID 121841 reaction equation
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][CH2:9][n:10]1[cH:11][n:12][c:13]2[c:14]1[cH:15][cH:16][cH:17][cH:18]2.[CH2:24]([CH3:25])[O:26][c:27]1[cH:28][c:29]([O:44][CH:45]([CH3:46])[CH3:47])[c:30]([F:43])[c:31]([CH:32]=[N:33][c:34]2[cH:35][cH:36][c:37]([C:38]#[N:39])[cH:40][cH:41]2)[cH:42]1.[CH2:48]1[O:49][CH2:50][CH2:51][CH2:52]1.[CH3:19][CH2:20][CH2:21][CH2:22][Li:23]>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][CH2:9][n:10]1[c:11]([N:33]([CH2:32][c:31]2[c:30]([F:43])[c:29]([O:44][CH:45]([CH3:46])[CH3:47])[cH:28][c:27]([O:26][CH2:24][CH3:25])[cH:42]2)[c:34]2[cH:35][cH:36][c:37]([C:38]#[N:39])[cH:40][cH:41]2)[n:12][c:13]2[c:14]1[cH:15][cH:16][cH:17][cH:18]2

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 113223751-benzyloxymethyl-1H-benzimidazoleHCID 57804014(E)-4-(5-ethoxy-2-fluoro-3-isopropoxybenzylideneamino)benzonitrileHCID 178418339Butyllithium

Product 1

HCID 688137704-((1-(benzyloxymethyl)-1H-benzo[d]imidazol-2-yl)(5-ethoxy-2-fluoro-3-isopropoxyphenyl)methylamino)benzonitrile

Sources & evidence

ORD record
ord-2002bd488c0646b4bb5edab2162d6fd6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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