Methanol → Tert-butyl 5-[2-amino-3-(3,5-difluorophenyl)-1-hydroxypropyl]-2-(2,2-dimethylpropoxy)morpholine-4-carboxylate
Reaction equation
[BH4-:1].[C:3]([CH3:4])([CH3:5])([CH3:6])[O:7][C:8](=[O:9])[N:10]1[CH2:11][CH:12]([O:31][CH2:32][C:33]([CH3:34])([CH3:35])[CH3:36])[O:13][CH2:14][CH:15]1[CH:16]([CH:17]([CH2:18][c:19]1[cH:20][c:21]([F:26])[cH:22][c:23]([F:25])[cH:24]1)[N+:27]([O-:28])=[O:29])[OH:30].[CH3:38][OH:39].[Cl:40][Ni:41][Cl:42].[Na+:2].[OH2:37]>>[C:3]([CH3:4])([CH3:5])([CH3:6])[O:7][C:8](=[O:9])[N:10]1[CH2:11][CH:12]([O:31][CH2:32][C:33]([CH3:34])([CH3:35])[CH3:36])[O:13][CH2:14][CH:15]1[CH:16]([CH:17]([CH2:18][c:19]1[cH:20][c:21]([F:26])[cH:22][c:23]([F:25])[cH:24]1)[NH2:27])[OH:30]Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-4154c6cd35204eea9b565bd10a903eb7
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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