1,2-Dichloroethane → tert-Butyl 4-(2-hydroxyethylamino)piperidine-1-carboxylate

HRID 1219190Notes

Reaction equation

HRID 1219190 reaction equation
[C:19]([O:20][BH-:21]([O:22][C:23](=[O:24])[CH3:25])[O:26][C:27](=[O:28])[CH3:29])(=[O:30])[CH3:31].[CH3:39][C:40](=[O:41])[OH:42].[Cl:35][CH2:36][CH2:37][Cl:38].[NH2:15][CH2:16][CH2:17][OH:18].[Na+:32].[Na+:34].[O:1]=[C:2]1[CH2:3][CH2:4][N:5]([C:8](=[O:9])[O:10][C:11]([CH3:12])([CH3:13])[CH3:14])[CH2:6][CH2:7]1.[OH-:33]>>[CH:2]1([NH:15][CH2:16][CH2:17][OH:18])[CH2:3][CH2:4][N:5]([C:8](=[O:9])[O:10][C:11]([CH3:12])([CH3:13])[CH3:14])[CH2:6][CH2:7]1

Participants

8

Reactant 7

HCID 111,2-DichloroethaneHCID 176Acetic AcidHCID 700EthanolamineHCID 923Sodium ion2×HCID 961HydroxideHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylateHCID 2724942Triacetoxyborohydride

Product 1

HCID 23131007tert-Butyl 4-(2-hydroxyethylamino)piperidine-1-carboxylate

Sources & evidence

ORD record
ord-317ec3d91b824b19ad6b1557af334f78
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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