Dichloromethane → Trifluoroacetic acid

HRID 1219191Notes

Reaction equation

HRID 1219191 reaction equation
[Cl:39][CH2:40][Cl:41].[F:1][c:2]1[c:3]([N:12]2[CH2:13][CH2:14][c:15]3[c:16]2[n:17][cH:18][n:19][c:20]3[O:21][CH:22]2[CH2:23][CH2:24][N:25]([C:28]([O:29][CH3:30])=[O:31])[CH2:26][CH2:27]2)[cH:4][cH:5][c:6]([S:8](=[O:9])(=[O:10])[CH3:11])[cH:7]1.[F:32][C:33]([C:34](=[O:35])[OH:36])([F:37])[F:38]>>[F:1][c:2]1[c:3]([N:12]2[CH2:13][CH2:14][c:15]3[c:16]2[n:17][cH:18][n:19][c:20]3[O:21][CH:22]2[CH2:23][CH2:24][NH:25][CH2:26][CH2:27]2)[cH:4][cH:5][c:6]([S:8](=[O:9])(=[O:10])[CH3:11])[cH:7]1.[F:32][C:33]([C:34](=[O:35])[OH:36])([F:37])[F:38]

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 24897458Methyl 4-[[7-(2-fluoro-4-methylsulfonylphenyl)-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]oxy]piperidine-1-carboxylate

Product 2

HCID 6422Trifluoroacetic acidHCID 690641277-(2-Fluoro-4-methylsulfonylphenyl)-4-piperidin-4-yloxy-5,6-dihydropyrrolo[2,3-d]pyrimidine

Sources & evidence

ORD record
ord-6b452584dcbc4b00b24bb1b5db229015
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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