Methanol → 2-Chloro-4-[4-hydroxymethyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-benzonitrile
Reaction equation
[CH3:47][OH:48].[Cl:1][c:2]1[c:3]([C:4]#[N:5])[cH:6][cH:7][c:8]([O:10][CH2:11][c:12]2[c:13]([CH2:27][O:28][CH:29]3[CH2:30][CH2:31][CH2:32][CH2:33][O:34]3)[n:14][c:15](-[c:17]3[cH:18][cH:19][c:20]([C:23]([F:24])([F:25])[F:26])[cH:21][cH:22]3)[s:16]2)[cH:9]1.[OH2:35].[c:36]1([CH3:37])[cH:38][cH:39][c:40]([S:41]([OH:42])(=[O:43])=[O:44])[cH:45][cH:46]1>>[Cl:1][c:2]1[c:3]([C:4]#[N:5])[cH:6][cH:7][c:8]([O:10][CH2:11][c:12]2[c:13]([CH2:27][OH:28])[n:14][c:15](-[c:17]3[cH:18][cH:19][c:20]([C:23]([F:24])([F:25])[F:26])[cH:21][cH:22]3)[s:16]2)[cH:9]1Participants
5
Reactant 4
Product 1
Sources & evidence
- ORD record
- ord-1eb7a751488140218cbc0282789d0a92
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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