Dimethylformamide → 1-Cyclopropylmethyl-piperidine-4-carboxylic Acid 4-[(4-chloro-phenyl)-methyl-carbamoyl]-2-methyl-benzylamide

HRID 1219778Notes

Reaction equation

HRID 1219778 reaction equation
[CH:1]1([CH2:4][N:5]2[CH2:6][CH2:7][CH:8]([C:11](=[O:12])[OH:13])[CH2:9][CH2:10]2)[CH2:2][CH2:3]1.[Cl:34][CH2:35][Cl:36].[NH2:14][CH2:15][c:16]1[c:17]([CH3:33])[cH:18][c:19]([C:20](=[O:21])[N:22]([CH3:23])[c:24]2[cH:25][cH:26][c:27]([Cl:30])[cH:28][cH:29]2)[cH:31][cH:32]1.[O:37]=[CH:38][N:39]([CH3:40])[CH3:41]>>[CH:1]1([CH2:4][N:5]2[CH2:6][CH2:7][CH:8]([C:11](=[O:13])[NH:14][CH2:15][c:16]3[c:17]([CH3:33])[cH:18][c:19]([C:20](=[O:21])[N:22]([CH3:23])[c:24]4[cH:25][cH:26][c:27]([Cl:30])[cH:28][cH:29]4)[cH:31][cH:32]3)[CH2:9][CH2:10]2)[CH2:2][CH2:3]1

Participants

5

Reactant 4

HCID 6228DimethylformamideHCID 6344DichloromethaneHCID 162440151-(Cyclopropylmethyl)piperidine-4-carboxylic acidHCID 575552204-Aminomethyl-N-(4-chloro-phenyl)-3,N-dimethyl-benzamide

Product 1

HCID 575552361-Cyclopropylmethyl-piperidine-4-carboxylic Acid 4-[(4-chloro-phenyl)-methyl-carbamoyl]-2-methyl-benzylamide

Sources & evidence

ORD record
ord-f716360f093d4f11a36cbf52718e36a3
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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