Dichloromethane → 1-(5-Tert-butylisoxazol-3-yl)-3-(3-{6-methoxy-7-[1-(2,2,2-trifluoroethyl)piperidin-4-yloxy]quinazolin-4-yloxy}phenyl)urea
Reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[c:5]1[cH:6][c:7]([NH:10][C:11](=[O:12])[NH:13][c:14]2[cH:15][c:16]([O:20][c:21]3[n:22][cH:23][n:24][c:25]4[cH:26][c:27]([O:33][CH:34]5[CH2:35][CH2:36][NH:37][CH2:38][CH2:39]5)[c:28]([O:31][CH3:32])[cH:29][c:30]34)[cH:17][cH:18][cH:19]2)[n:8][o:9]1.[CH:53]([N:54]([CH2:55][CH3:56])[CH:57]([CH3:58])[CH3:59])([CH3:60])[CH3:61].[Cl:62][CH2:63][Cl:64].[F:40][C:41]([F:42])([F:43])[S:44]([O:45][CH2:46][C:47]([F:48])([F:49])[F:50])(=[O:51])=[O:52]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[c:5]1[cH:6][c:7]([NH:10][C:11](=[O:12])[NH:13][c:14]2[cH:15][c:16]([O:20][c:21]3[n:22][cH:23][n:24][c:25]4[cH:26][c:27]([O:33][CH:34]5[CH2:35][CH2:36][N:37]([CH2:46][C:47]([F:48])([F:49])[F:50])[CH2:38][CH2:39]5)[c:28]([O:31][CH3:32])[cH:29][c:30]34)[cH:17][cH:18][cH:19]2)[n:8][o:9]1Participants
5
Reactant 4
Product 1
Sources & evidence
- ORD record
- ord-b4fa340bb5524e4dade2a6457ef59d09
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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