Dichloromethane → 4-(5-chloro-[1H]-indol-3-yl)-piperidine

HRID 1220525Notes

Reaction equation

HRID 1220525 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH2:10][CH:11]([c:14]2[cH:15][nH:16][c:17]3[cH:18][cH:19][c:20]([Cl:23])[cH:21][c:22]23)[CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[Cl:31][CH2:32][Cl:33].[F:24][C:25]([F:26])([F:27])[C:28]([OH:29])=[O:30]>>[NH:8]1[CH2:9][CH2:10][CH:11]([c:14]2[cH:15][nH:16][c:17]3[cH:18][cH:19][c:20]([Cl:23])[cH:21][c:22]23)[CH2:12][CH2:13]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 12072033tert-butyl 4-(5-chloro-1H-indol-3-yl)piperidine-1-carboxylate

Product 1

HCID 128313754-(5-chloro-[1H]-indol-3-yl)-piperidine

Sources & evidence

ORD record
ord-31d5303c7b8b43c0bd62e05358598da5
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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