Dichloromethane → 5-chloro-1-(2,6-difluorophenyl)-7-[4-(1-pyrrolidinyl)-1-piperidinyl]-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one

HRID 1220993Notes

Reaction equation

HRID 1220993 reaction equation
[CH:35]([N:36]([CH2:37][CH3:38])[CH:39]([CH3:40])[CH3:41])([CH3:42])[CH3:43].[Cl:1][c:2]1[c:3]2[c:4]([n:5][c:6]([S:8]([CH3:9])=[O:10])[n:7]1)[N:11]([c:16]1[c:17]([F:23])[cH:18][cH:19][cH:20][c:21]1[F:22])[C:12](=[O:15])[NH:13][CH2:14]2.[Cl:44][CH2:45][Cl:46].[N:24]1([CH:29]2[CH2:30][CH2:31][NH:32][CH2:33][CH2:34]2)[CH2:25][CH2:26][CH2:27][CH2:28]1>>[Cl:1][c:2]1[c:3]2[c:4]([n:5][c:6]([N:32]3[CH2:31][CH2:30][CH:29]([N:24]4[CH2:25][CH2:26][CH2:27][CH2:28]4)[CH2:34][CH2:33]3)[n:7]1)[N:11]([c:16]1[c:17]([F:23])[cH:18][cH:19][cH:20][c:21]1[F:22])[C:12](=[O:15])[NH:13][CH2:14]2

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 787034-(1-Pyrrolidinyl)piperidineHCID 81531DiisopropylethylamineHCID 57530505HCID 57530505, compound

Product 1

HCID 119516925-chloro-1-(2,6-difluorophenyl)-7-[4-(1-pyrrolidinyl)-1-piperidinyl]-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one

Sources & evidence

ORD record
ord-7d1af6f43534465484fcf4e1be50269c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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