Bromide ion → Ethyl 4-(4-(cyclohexylmethyl)-4-hydroxypiperidin-1-yl)benzoate

HRID 1221053Notes

Reaction equation

HRID 1221053 reaction equation
[Br-:1].[CH2:28]1[O:29][CH2:30][CH2:31][CH2:32]1.[CH:2]1([CH2:8][Mg+:9])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7]1.[O:10]=[C:11]1[CH2:12][CH2:13][N:14]([c:17]2[cH:18][cH:19][c:20]([C:21](=[O:22])[O:23][CH2:24][CH3:25])[cH:26][cH:27]2)[CH2:15][CH2:16]1>>[CH:2]1([CH2:8][C:11]2([OH:10])[CH2:12][CH2:13][N:14]([c:17]3[cH:18][cH:19][c:20]([C:21](=[O:22])[O:23][CH2:24][CH3:25])[cH:26][cH:27]3)[CH2:15][CH2:16]2)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7]1

Participants

5

Reactant 4

HCID 259Bromide ionHCID 8028TetrahydrofuranHCID 12717442Ethyl 4-(4-oxopiperidin-1-yl)benzoateHCID 178507044HCID 178507044, compound

Product 1

HCID 16109048Ethyl 4-(4-(cyclohexylmethyl)-4-hydroxypiperidin-1-yl)benzoate

Sources & evidence

ORD record
ord-78c20249fa314104b40564081f12c91f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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