Dichloromethane → [6-[2-[2-(Cyclopropylmethoxy)-3-methoxyphenyl]ethenyl]imidazo[2,1-b][1,3]thiazol-5-yl]-[4-[5-(trifluoromethyl)-2-pyridinyl]piperazin-1-yl]methanone
Reaction equation
[CH3:43][CH2:44][N:45]([CH2:46][CH3:47])[CH2:48][CH3:49].[CH:1]1([CH2:4][O:5][c:6]2[c:7]([CH:14]=[CH:15][c:16]3[n:17][c:18]4[s:19][cH:20][cH:21][n:22]4[c:23]3[C:24](=[O:25])[OH:26])[cH:8][cH:9][cH:10][c:11]2[O:12][CH3:13])[CH2:2][CH2:3]1.[Cl:50][CH2:51][Cl:52].[F:27][C:28]([c:29]1[cH:30][cH:31][c:32]([N:35]2[CH2:36][CH2:37][NH:38][CH2:39][CH2:40]2)[n:33][cH:34]1)([F:41])[F:42]>>[CH:1]1([CH2:4][O:5][c:6]2[c:7]([CH:14]=[CH:15][c:16]3[n:17][c:18]4[s:19][cH:20][cH:21][n:22]4[c:23]3[C:24](=[O:25])[N:38]3[CH2:37][CH2:36][N:35]([c:32]4[cH:31][cH:30][c:29]([C:28]([F:27])([F:41])[F:42])[cH:34][n:33]4)[CH2:40][CH2:39]3)[cH:8][cH:9][cH:10][c:11]2[O:12][CH3:13])[CH2:2][CH2:3]1Participants
5
Reactant 4
Product 1
Sources & evidence
- ORD record
- ord-aa7cfa03470242a09ead2993aec627e9
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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