1,4-Dioxane → 6-[4-(2,3-Dihydroxypropyl)piperazin-1-yl]nicotinic acid

HRID 1221479Notes

Reaction equation

HRID 1221479 reaction equation
[Cl:1][c:2]1[n:3][cH:4][c:5]([C:6](=[O:7])[OH:8])[cH:9][cH:10]1.[O:22]1[CH2:23][CH2:24][O:25][CH2:26][CH2:27]1.[OH:11][CH:12]([CH2:13][N:14]1[CH2:15][CH2:16][NH:17][CH2:18][CH2:19]1)[CH2:20][OH:21]>>[c:2]1([N:17]2[CH2:16][CH2:15][N:14]([CH2:13][CH:12]([OH:11])[CH2:20][OH:21])[CH2:19][CH2:18]2)[n:3][cH:4][c:5]([C:6](=[O:7])[OH:8])[cH:9][cH:10]1

Participants

4

Reactant 3

HCID 312751,4-DioxaneHCID 792226-Chloronicotinic acidHCID 1110023-(Piperazin-1-yl)propane-1,2-diol

Product 1

HCID 200320136-[4-(2,3-Dihydroxypropyl)piperazin-1-yl]nicotinic acid

Sources & evidence

ORD record
ord-b419d125db5b45aa9cbdb4f2392380f7
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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