Tetrahydrofuran → 1-(2',5'-Difluoro-4-(hydroxymethyl)-1,1'-biphenyl-2-yl)-2,2-dimethyl-1-propanone
Reaction equation
[C:21]([CH3:22])([CH3:23])([CH3:24])[Li:25].[CH2:26]1[O:27][CH2:28][CH2:29][CH2:30]1.[F:1][c:2]1[c:3](-[c:9]2[c:10]([C:17]([O:19][CH3:18])=[O:20])[cH:11][c:12]([CH2:15][OH:16])[cH:13][cH:14]2)[cH:4][c:5]([F:8])[cH:6][cH:7]1>>[F:1][c:2]1[c:3](-[c:9]2[c:10]([C:17](=[O:19])[C:21]([CH3:22])([CH3:23])[CH3:24])[cH:11][c:12]([CH2:15][OH:16])[cH:13][cH:14]2)[cH:4][c:5]([F:8])[cH:6][cH:7]1Participants
4
Sources & evidence
- ORD record
- ord-e6aa8091f6294ee1b5d967f600ca67a6
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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