1,8-Diazabicyclo(5.4.0)undec-7-ene → 3-(5-morpholin-4-ylpyridin-3-yl)-3-[4-(7-[2-(trimethylsilyl)-ethoxy]methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile

HRID 1222178Notes

Reaction equation

HRID 1222178 reaction equation
[CH2:39]1[CH2:40][CH2:41][C:42]2=[N:47][CH2:46][CH2:45][CH2:44][N:43]2[CH2:48][CH2:49]1.[O:23]1[CH2:24][CH2:25][N:26]([c:29]2[cH:30][c:31]([CH:35]=[CH:36][C:37]#[N:38])[cH:32][n:33][cH:34]2)[CH2:27][CH2:28]1.[nH:1]1[n:2][cH:3][c:4](-[c:6]2[c:7]3[c:8]([n:9][cH:10][n:11]2)[n:12]([CH2:15][O:16][CH2:17][CH2:18][Si:19]([CH3:20])([CH3:21])[CH3:22])[cH:13][cH:14]3)[cH:5]1>>[n:1]1([CH:35]([c:31]2[cH:30][c:29]([N:26]3[CH2:25][CH2:24][O:23][CH2:28][CH2:27]3)[cH:34][n:33][cH:32]2)[CH2:36][C:37]#[N:38])[n:2][cH:3][c:4](-[c:6]2[c:7]3[c:8]([n:9][cH:10][n:11]2)[n:12]([CH2:15][O:16][CH2:17][CH2:18][Si:19]([CH3:20])([CH3:21])[CH3:22])[cH:13][cH:14]3)[cH:5]1

Participants

4

Reactant 3

HCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 426313464-(1H-Pyrazol-4-yl)-7-(2-(trimethylsilyl)ethoxy)methyl-7 H-pyrrolo(2,3-d)-pyrimidineHCID 665971773-(5-Morpholin-4-ylpyridin-3-yl)acrylonitrile

Product 1

HCID 574778973-(5-morpholin-4-ylpyridin-3-yl)-3-[4-(7-[2-(trimethylsilyl)-ethoxy]methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile

Sources & evidence

ORD record
ord-61ae5e5115f74a529f1b408b4001a897
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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