Acetate → Benzyl 3-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-4-(4-pyrrolidin-1-ylphenyl)piperidine-1-carboxylate

HRID 1222468Notes

Reaction equation

HRID 1222468 reaction equation
[C:53](=[O:54])([O-:55])[O-:56].[CH2:48]1[CH2:49][CH2:50][NH:51][CH2:52]1.[CH3:1][O:2][CH2:3][CH2:4][CH2:5][N:6]1[CH2:7][CH2:8][O:9][c:10]2[c:11]1[cH:12][c:13]([CH2:16][O:17][CH:18]1[CH2:19][N:20]([C:38](=[O:39])[O:40][CH2:41][c:42]3[cH:43][cH:44][cH:45][cH:46][cH:47]3)[CH2:21][CH2:22][CH:23]1[c:24]1[cH:25][cH:26][c:27]([O:30][S:31]([C:32]([F:33])([F:34])[F:35])(=[O:36])=[O:37])[cH:28][cH:29]1)[cH:14][cH:15]2.[Cs+:57].[Cs+:58].[O-:67][C:68]([CH3:69])=[O:70].[O-:71][C:72]([CH3:73])=[O:74].[O:60]1[CH2:61][CH2:62][O:63][CH2:64][CH2:65]1.[OH2:59].[Pd+2:66]>>[CH3:1][O:2][CH2:3][CH2:4][CH2:5][N:6]1[CH2:7][CH2:8][O:9][c:10]2[c:11]1[cH:12][c:13]([CH2:16][O:17][CH:18]1[CH2:19][N:20]([C:38](=[O:39])[O:40][CH2:41][c:42]3[cH:43][cH:44][cH:45][cH:46][cH:47]3)[CH2:21][CH2:22][CH:23]1[c:24]1[cH:25][cH:26][c:27]([N:51]3[CH2:50][CH2:49][CH2:48][CH2:52]3)[cH:28][cH:29]1)[cH:14][cH:15]2

Participants

9

Reactant 8

HCID 175Acetate2×HCID 962WaterHCID 19660Carbonate IonHCID 31268PyrrolidineHCID 312751,4-DioxaneHCID 104967Cesium cation2×HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 86610023benzyl 3-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-4-(4-trifluoromethanesulphonyloxyphenyl)piperidin-1-carboxylate

Product 1

HCID 68503530Benzyl 3-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-4-(4-pyrrolidin-1-ylphenyl)piperidine-1-carboxylate

Sources & evidence

ORD record
ord-0ca353ba3430423a8f2eb2d536624065
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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