HRID12228

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID229163

4-Methylnicotinic acid

C7H7NO2

结构：C[C@H](N)CN1CC(C)(C)OC[C@H]1C(=O)Nc1cc(Cl)cc2c1[nH]c1cnccc12.O=C(O)C(F)(F)F

HCID67165199

未命名化合物

PRODUCTS

生成物

结构：Cc1ccncc1C(=O)N[C@@H](C)CN1CC(C)(C)OC[C@H]1C(=O)Nc1cc(Cl)cc2c1[nH]c1cnccc12

HCID59277731

未命名化合物

收率 79%

PROCEDURE

实验过程

The desired compound was prepared according to Method E from (S)-4-((S)-2-Amino-propyl)-6,6-dimethyl-morpholine-3-carboxylic acid (6-chloro-9H-beta-carbolin-8-yl)-amide trifluoroacetate salt and 4-methyl-nicotinic acid in 79% yield.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1b856251211042118c2fe543f99e5df8
来源数据集: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07727985B2
来源说明: uspto-grants-2010_06

反应 SMILES

FC(F)(F)C(O)=O.[Cl:8][C:9]1[CH:10]=[C:11]2[C:19](=[C:20]([NH:22][C:23]([C@@H:25]3[CH2:30][O:29][C:28]([CH3:32])([CH3:31])[CH2:27][N:26]3[CH2:33][C@@H:34]([NH2:36])[CH3:35])=[O:24])[CH:21]=1)[NH:18][C:17]1[CH:16]=[N:15][CH:14]=[CH:13][C:12]2=1.[CH3:37][C:38]1[C:43]([C:44](O)=[O:45])=[CH:42][N:41]=[CH:40][CH:39]=1>>[Cl:8][C:9]1[CH:10]=[C:11]2[C:19](=[C:20]([NH:22][C:23]([C@@H:25]3[CH2:30][O:29][C:28]([CH3:31])([CH3:32])[CH2:27][N:26]3[CH2:33][C@@H:34]([NH:36][C:44]([C:43]3[CH:42]=[N:41][CH:40]=[CH:39][C:38]=3[CH3:37])=[O:45])[CH3:35])=[O:24])[CH:21]=1)[NH:18][C:17]1[CH:16]=[N:15][CH:14]=[CH:13][C:12]2=1