HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylnicotinic acid → (S)-6,6-Dimethyl-4-{(S)-2-[(4-methyl-pyridine-3-carbonyl)-amino]-propyl}-morpholine-3-carboxylic acid (6-chloro-9H-beta-carbolin-8-yl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylnicotinic acid | HCID 229163 | — |
| Reactant | (s)-4-((s)-2-Amino-propyl)-6,6-dimethyl-morpholine-3-carboxylic acid (6-chloro-9h-beta-carbolin-8-yl)-amide trifluoroacetate salt | HCID 67165199 | — |
| Product | (S)-6,6-Dimethyl-4-{(S)-2-[(4-methyl-pyridine-3-carbonyl)-amino]-propyl}-morpholine-3-carboxylic acid (6-chloro-9H-beta-carbolin-8-yl)-amide | HCID 59277731 | 79% |
Reaction Steps
The desired compound was prepared according to Method E from (S)-4-((S)-2-Amino-propyl)-6,6-dimethyl-morpholine-3-carboxylic acid (6-chloro-9H-beta-carbolin-8-yl)-amide trifluoroacetate salt and 4-methyl-nicotinic acid in 79% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07727985B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-1b856251211042118c2fe543f99e5df8 |
| Source note | uspto-grants-2010_06 |