Tetrahydrofuran → 8-(4-Fluorophenyl)-1-(3-hydroxypropyl)-N,N,2-trimethyl-1,6,7,8-tetrahydrochromeno[7,8-d]imidazole-5-carboxamide

HRID 1222982Notes

Reaction equation

[C:1]([Si:2]([CH3:3])([CH3:4])[O:6][CH2:7][CH2:8][CH2:9][n:10]1[c:11]([CH3:35])[n:12][c:13]2[c:14]1[c:15]1[c:20]([c:21]([C:23](=[O:24])[N:25]([CH3:26])[CH3:27])[cH:22]2)[CH2:19][CH2:18][CH:17]([c:28]2[cH:29][cH:30][c:31]([F:34])[cH:32][cH:33]2)[O:16]1)([CH3:5])([CH3:36])[CH3:37].[CH3:39][CH2:40][CH2:41][CH2:42][N+:43]([CH2:44][CH2:45][CH2:46][CH3:47])([CH2:48][CH2:49][CH2:50][CH3:51])[CH2:52][CH2:53][CH2:54][CH3:55].[F-:38].[O:56]1[CH2:57][CH2:58][CH2:59][CH2:60]1>>[OH:6][CH2:7][CH2:8][CH2:9][n:10]1[c:11]([CH3:35])[n:12][c:13]2[c:14]1[c:15]1[c:20]([c:21]([C:23](=[O:24])[N:25]([CH3:26])[CH3:27])[cH:22]2)[CH2:19][CH2:18][CH:17]([c:28]2[cH:29][cH:30][c:31]([F:34])[cH:32][cH:33]2)[O:16]1

Participants

Reactant 4

HCID 8028Tetrahydrofuran

HCID 16028Tetrabutylammonium

HCID 28179Fluoride Ion

HCID 672206591-(3-{[tert-Butyl(dimethyl)silyl]oxy}propyl)-8-(4-fluorophenyl)-N,N,2-trimethyl-1,6,7,8-tetrahydrochromeno[7,8-d]imidazole-5-carboxamide

Product 1

HCID 248607018-(4-Fluorophenyl)-1-(3-hydroxypropyl)-N,N,2-trimethyl-1,6,7,8-tetrahydrochromeno[7,8-d]imidazole-5-carboxamide

Sources & evidence

ORD record: ord-fe86b086fbb445859259b6d4a26f5b03
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (5/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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