Bromobenzene → 2-(3-Bromo-phenyl)-6-cyclopropyl-4-(4-trifluoromethyl-phenyl)-pyridine

HRID 1223328Notes

Reaction equation

HRID 1223328 reaction equation
[BH:28]([OH:29])[OH:30].[Br:31][c:32]1[cH:33][cH:34][cH:35][cH:36][cH:37]1.[CH:1]1([c:4]2[cH:5][c:6](-[c:18]3[cH:19][cH:20][c:21]([C:24]([F:25])([F:26])[F:27])[cH:22][cH:23]3)[cH:7][c:8]([O:10][S:11]([C:12]([F:13])([F:14])[F:15])(=[O:16])=[O:17])[n:9]2)[CH2:2][CH2:3]1>>[CH:1]1([c:4]2[cH:5][c:6](-[c:18]3[cH:19][cH:20][c:21]([C:24]([F:25])([F:26])[F:27])[cH:22][cH:23]3)[cH:7][c:8](-[c:36]3[cH:35][cH:34][cH:33][c:32]([Br:31])[cH:37]3)[n:9]2)[CH2:2][CH2:3]1

Participants

4

Reactant 3

HCID 7961BromobenzeneHCID 61668Boronic AcidHCID 57468747Trifluoro-methanesulfonic acid 6-cyclopropyl-4-(4-trifluoromethyl-phenyl)-pyridin-2-yl ester

Product 1

HCID 574687462-(3-Bromo-phenyl)-6-cyclopropyl-4-(4-trifluoromethyl-phenyl)-pyridine

Sources & evidence

ORD record
ord-169567ff52604c6782c05056f7fd7471
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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