Methanol → N-(2,6-difluorophenyl)-3-{3-[2-({5-fluoro-2-(methyloxy)-4-[2-(1-piperidinyl)ethyl]phenyl}amino)-4-pyrimidinyl]imidazo[1,2-a]pyridin-2-yl}benzamide
Reaction equation
[CH2:65]1[O:66][CH2:67][CH2:68][CH2:69]1.[CH3:11][Si:12]([N-:13][Si:14]([CH3:15])([CH3:16])[CH3:17])([CH3:18])[CH3:19].[CH3:63][OH:64].[F:1][c:2]1[c:3]([NH2:4])[c:5]([F:9])[cH:6][cH:7][cH:8]1.[F:20][c:21]1[c:22]([CH2:55][CH2:56][N:57]2[CH2:58][CH2:59][CH2:60][CH2:61][CH2:62]2)[cH:23][c:24]([O:53][CH3:54])[c:25]([NH:27][c:28]2[n:29][cH:30][cH:31][c:32](-[c:34]3[c:35](-[c:43]4[cH:44][c:45]([C:46](=[O:47])[O:48][CH3:49])[cH:50][cH:51][cH:52]4)[n:36][c:37]4[n:38]3[cH:39][cH:40][cH:41][cH:42]4)[n:33]2)[cH:26]1.[Na+:10]>>[F:1][c:2]1[c:3]([NH:4][C:46]([c:45]2[cH:44][c:43](-[c:35]3[c:34](-[c:32]4[cH:31][cH:30][n:29][c:28]([NH:27][c:25]5[c:24]([O:53][CH3:54])[cH:23][c:22]([CH2:55][CH2:56][N:57]6[CH2:58][CH2:59][CH2:60][CH2:61][CH2:62]6)[c:21]([F:20])[cH:26]5)[n:33]4)[n:38]4[c:37]([n:36]3)[cH:42][cH:41][cH:40][cH:39]4)[cH:52][cH:51][cH:50]2)=[O:47])[c:5]([F:9])[cH:6][cH:7][cH:8]1Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-d8cd0f5b8cac46e28ce289a4b420a238
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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