Hydrochloric Acid → [4-(2-Pyrrolidin-1-yl-ethoxy)-2-trifluoromethyl-phenyl]-(5-thiophen-3-yl-thiazol-2-yl)-amine

HRID 1223455Notes

Reaction equation

HRID 1223455 reaction equation
[CH3:1][N:2]([CH3:3])[CH2:4][CH2:5][CH2:6][O:7][c:8]1[cH:9][cH:10][c:11](-[c:12]2[s:13][c:14]([NH:15][c:16]3[cH:17][cH:18][cH:19][cH:20][cH:21]3)[n:22][cH:23]2)[cH:24][cH:25]1.[CH3:60][OH:61].[Cl:49][CH2:50][CH2:51][N:52]1[CH2:53][CH2:54][CH2:55][CH2:56]1.[Cl:57][CH2:58][Cl:59].[ClH:48].[s:26]1[cH:27][c:28](-[c:31]2[cH:32][n:33][c:34]([NH:36][c:37]3[c:38]([C:44]([F:45])([F:46])[F:47])[cH:39][c:40]([OH:43])[cH:41][cH:42]3)[s:35]2)[cH:29][cH:30]1>>[s:26]1[cH:27][c:28](-[c:31]2[cH:32][n:33][c:34]([NH:36][c:37]3[c:38]([C:44]([F:45])([F:46])[F:47])[cH:39][c:40]([O:43][CH2:50][CH2:51][N:52]4[CH2:53][CH2:54][CH2:55][CH2:56]4)[cH:41][cH:42]3)[s:35]2)[cH:29][cH:30]1

Participants

7

Reactant 6

HCID 313Hydrochloric AcidHCID 887MethanolHCID 6344DichloromethaneHCID 816691-(2-Chloroethyl)pyrrolidineHCID 11245147{5-[4-(3-Dimethylamino-propoxy)-phenyl]-thiazol-2-yl}phenyl-amineHCID 589235234-(5-Thiophen-3-yl-thiazol-2-ylamino)-3-trifluoromethyl-phenol

Product 1

HCID 58923519[4-(2-Pyrrolidin-1-yl-ethoxy)-2-trifluoromethyl-phenyl]-(5-thiophen-3-yl-thiazol-2-yl)-amine

Sources & evidence

ORD record
ord-6d90f376331648ebabb0aeb96b381d0c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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