Toluene → {4-[2-(2,4-Dichloro-phenyl)-1-hydroxy-1-trifluoromethyl-propyl]-pyridin-2-yloxy}-acetic acid methyl ester

HRID 1223725Notes

Reaction equation

HRID 1223725 reaction equation
[Ag+2:41].[C:37](=[O:38])([O-:39])[O-:40].[CH3:24][O:25][C:26]([CH2:27][Br:28])=[O:29].[CH3:30][c:31]1[cH:32][cH:33][cH:34][cH:35][cH:36]1.[Cl:1][c:2]1[c:3]([CH:9]([C:10]([C:11]([F:12])([F:13])[F:14])([OH:15])[c:16]2[cH:17][c:18](=[O:22])[nH:19][cH:20][cH:21]2)[CH3:23])[cH:4][cH:5][c:6]([Cl:8])[cH:7]1>>[Cl:1][c:2]1[c:3]([CH:9]([C:10]([C:11]([F:12])([F:13])[F:14])([OH:15])[c:16]2[cH:17][c:18]([O:22][CH2:27][C:26]([O:25][CH3:24])=[O:29])[n:19][cH:20][cH:21]2)[CH3:23])[cH:4][cH:5][c:6]([Cl:8])[cH:7]1

Participants

6

Reactant 5

HCID 1140TolueneHCID 19660Carbonate IonHCID 60984Methyl bromoacetateHCID 57421256HCID 57421256, compoundHCID 178419107HCID 178419107, compound

Product 1

HCID 25254606{4-[2-(2,4-Dichloro-phenyl)-1-hydroxy-1-trifluoromethyl-propyl]-pyridin-2-yloxy}-acetic acid methyl ester

Sources & evidence

ORD record
ord-5dc116428bc54c88bedd33629b0a5e3f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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