Dichloromethane → 4-[4-(3-Pyrrolidin-1-ylpropoxy)phenyl]piperidine-4-carbonitrile

HRID 1224198Notes

Reaction equation

HRID 1224198 reaction equation
[C:1](#[N:2])[C:3]1([c:16]2[cH:17][cH:18][c:19]([O:22][CH2:23][CH2:24][CH2:25][N:26]3[CH2:27][CH2:28][CH2:29][CH2:30]3)[cH:20][cH:21]2)[CH2:4][CH2:5][N:6]([C:9]([O:10][C:11]([CH3:12])([CH3:13])[CH3:14])=[O:15])[CH2:7][CH2:8]1.[Cl:38][CH2:39][Cl:40].[OH:31][C:32]([C:33]([F:34])([F:35])[F:36])=[O:37]>>[C:1](#[N:2])[C:3]1([c:16]2[cH:17][cH:18][c:19]([O:22][CH2:23][CH2:24][CH2:25][N:26]3[CH2:27][CH2:28][CH2:29][CH2:30]3)[cH:20][cH:21]2)[CH2:4][CH2:5][NH:6][CH2:7][CH2:8]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 68578770Tert-butyl 4-cyano-4-[4-(3-pyrrolidin-1-ylpropoxy)phenyl]piperidine-1-carboxylate

Product 1

HCID 598373684-[4-(3-Pyrrolidin-1-ylpropoxy)phenyl]piperidine-4-carbonitrile

Sources & evidence

ORD record
ord-0af1aa050d0e4730bdd7cf4c0c530ef3
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

Loading…