1-(4-Bromo-phenyl)-2,2-difluoro-propan-1-ol → 2-(4-(2,2-Difluoro-1-hydroxypropyl)phenyl)-8-(3,3-dimethylbutanoyl)-2,8-diazaspiro[4.5]decan-1-one
Reaction equation
[Br:49][c:50]1[cH:51][cH:52][c:53]([CH:56]([C:57]([CH3:58])([F:59])[F:60])[OH:61])[cH:54][cH:55]1.[CH3:19][C:20]([CH3:21])([CH3:22])[CH2:23][C:24]([N:25]1[CH2:26][CH2:27][C:28]2([C:29](=[O:30])[N:31]([c:32]3[cH:33][cH:34][c:35]([CH:36]([OH:37])[C:38]([F:39])([F:40])[F:41])[cH:42][cH:43]3)[CH2:44][CH2:45]2)[CH2:46][CH2:47]1)=[O:48].[CH3:1][C:2]([CH2:3][C:4](=[O:5])[N:6]1[CH2:7][CH2:8][C:9]2([CH2:10][CH2:11][NH:12][C:13]2=[O:14])[CH2:15][CH2:16]1)([CH3:17])[CH3:18]>>[CH3:1][C:2]([CH2:3][C:4](=[O:5])[N:6]1[CH2:7][CH2:8][C:9]2([CH2:10][CH2:11][N:12]([c:50]3[cH:51][cH:52][c:53]([CH:56]([C:57]([CH3:58])([F:59])[F:60])[OH:61])[cH:54][cH:55]3)[C:13]2=[O:14])[CH2:15][CH2:16]1)([CH3:17])[CH3:18]Participants
4
Reactant 3
Product 1
Sources & evidence
- ORD record
- ord-e9a47187fc7d45e689e6facdfaccbcfe
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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