Acetonitrile → 3-(1,3-Benzoxazol-2-yl)-5-[3-methyl-1-(4-piperidyl)pyrazol-4-yl]pyridin-2-amine

HRID 1224315Notes

Reaction equation

HRID 1224315 reaction equation
[CH3:46][C:47]#[N:48].[Cl:43][CH2:44][Cl:45].[F:36][C:37]([F:38])([F:39])[C:40]([OH:41])=[O:42].[NH2:1][c:2]1[c:3](-[c:27]2[o:28][c:29]3[c:30]([n:31]2)[cH:32][cH:33][cH:34][cH:35]3)[cH:4][c:5](-[c:8]2[c:9]([CH3:26])[n:10][n:11]([CH:13]3[CH2:14][CH2:15][N:16]([C:19]([O:20][C:21]([CH3:22])([CH3:23])[CH3:24])=[O:25])[CH2:17][CH2:18]3)[cH:12]2)[cH:6][n:7]1>>[NH2:1][c:2]1[c:3](-[c:27]2[o:28][c:29]3[c:30]([n:31]2)[cH:32][cH:33][cH:34][cH:35]3)[cH:4][c:5](-[c:8]2[c:9]([CH3:26])[n:10][n:11]([CH:13]3[CH2:14][CH2:15][NH:16][CH2:17][CH2:18]3)[cH:12]2)[cH:6][n:7]1

Participants

5

Reactant 4

HCID 6342AcetonitrileHCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 57687030Tert-butyl 4-[4-[6-amino-5-(1,3-benzoxazol-2-yl)-3-pyridyl]-3-methyl-pyrazol-1-yl]piperidine-1-carboxylate

Product 1

HCID 425993613-(1,3-Benzoxazol-2-yl)-5-[3-methyl-1-(4-piperidyl)pyrazol-4-yl]pyridin-2-amine

Sources & evidence

ORD record
ord-1613c5147270492192fe280dc1846181
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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