Acetate → 1-(4-Fluorophenyl)-4-iodo-2-oxo-1,2-dihydropyridine-3-carbaldehyde

HRID 1224326Notes

Reaction equation

HRID 1224326 reaction equation
[C:52]([O-:53])(=[O:54])[CH3:55].[C:57]([O-:58])(=[O:59])[CH3:60].[CH3:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][C:34](=[O:35])[OH:36].[CH3:45][c:46]1[cH:47][cH:48][cH:49][cH:50][cH:51]1.[Cu+2:56].[I:1][c:2]1[c:3]([CH:9]=[O:10])[c:4](=[O:8])[nH:5][cH:6][cH:7]1.[OH:11][B:12]([OH:13])[c:14]1[cH:15][cH:16][c:17]([F:18])[cH:19][cH:20]1.[n:37]1[c:38]([CH3:39])[cH:40][cH:41][cH:42][c:43]1[CH3:44]>>[I:1][c:2]1[c:3]([CH:9]=[O:10])[c:4](=[O:8])[n:5](-[c:14]2[cH:15][cH:16][c:17]([F:18])[cH:19][cH:20]2)[cH:6][cH:7]1

Participants

8

Reactant 7

HCID 175Acetate2×HCID 1140TolueneHCID 79372,6-LutidineHCID 11005Myristic AcidHCID 27099Cupric cationHCID 2856454-Fluorophenylboronic acidHCID 184399262-Hydroxy-4-iodonicotinaldehyde

Product 1

HCID 252319761-(4-Fluorophenyl)-4-iodo-2-oxo-1,2-dihydropyridine-3-carbaldehyde

Sources & evidence

ORD record
ord-defd133fc10947999d582d6ab8cd0d41
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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