1,2-Dichloroethane → 2-(1-((5-(2-methyl-1H-benzo[d]imidazol-1-yl)-7-morpholinothiazolo[5,4-d]pyrimidin-2-yl)methyl)piperidin-3-yl)propan-2-ol

HRID 1224436Notes

Reaction equation

HRID 1224436 reaction equation
[C:42]([O:43][BH-:44]([O:45][C:46](=[O:47])[CH3:48])[O:49][C:50](=[O:51])[CH3:52])(=[O:53])[CH3:54].[CH3:1][c:2]1[n:3][c:4]2[c:5]([n:6]1-[c:7]1[n:8][c:9]([N:18]3[CH2:19][CH2:20][O:21][CH2:22][CH2:23]3)[c:10]3[c:11]([n:12]1)[s:13][c:14]([CH:16]=[O:17])[n:15]3)[cH:24][cH:25][cH:26][cH:27]2.[CH3:38][C:39](=[O:40])[OH:41].[Cl:56][CH2:57][CH2:58][Cl:59].[NH:28]1[CH2:29][CH:30]([C:34]([CH3:35])([CH3:36])[OH:37])[CH2:31][CH2:32][CH2:33]1.[Na+:55]>>[CH3:1][c:2]1[n:3][c:4]2[c:5]([n:6]1-[c:7]1[n:8][c:9]([N:18]3[CH2:19][CH2:20][O:21][CH2:22][CH2:23]3)[c:10]3[c:11]([n:12]1)[s:13][c:14]([CH2:16][N:28]1[CH2:29][CH:30]([C:34]([CH3:35])([CH3:36])[OH:37])[CH2:31][CH2:32][CH2:33]1)[n:15]3)[cH:24][cH:25][cH:26][cH:27]2

Participants

7

Reactant 6

HCID 111,2-DichloroethaneHCID 176Acetic AcidHCID 923Sodium ionHCID 2724942TriacetoxyborohydrideHCID 451571082-(3-Piperidinyl)-2-propanolHCID 866482585-(2-Methylbenzoimidazol-1-yl)-7-morpholin-4-yl-thiazolo[5,4-d]pyrimidine-2-carbaldehyde

Product 1

HCID 596056872-(1-((5-(2-methyl-1H-benzo[d]imidazol-1-yl)-7-morpholinothiazolo[5,4-d]pyrimidin-2-yl)methyl)piperidin-3-yl)propan-2-ol

Sources & evidence

ORD record
ord-a5340a08eecb477f89dbc9842951e552
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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