Hydrochloric Acid → 1-benzyl-3-{3-[4-(4-fluorophenyl)piperidin-1-yl]propyl}-5-methyl-1H-pyrimidine-2,4-dione
Reaction equation
[C:37](=[O:38])([O-:39])[O-:40].[CH2:15]([c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1)[n:22]1[c:23](=[O:34])[n:24]([CH2:30][CH2:31][CH2:32][Br:33])[c:25](=[O:29])[c:26]([CH3:28])[cH:27]1.[CH3:43][C:44]#[N:45].[Cl:46][CH2:47][Cl:48].[ClH:1].[F:2][c:3]1[cH:4][cH:5][c:6]([CH:9]2[CH2:10][CH2:11][NH:12][CH2:13][CH2:14]2)[cH:7][cH:8]1.[I-:36].[K+:41].[K+:42].[Na+:35].[OH2:49]>>[F:2][c:3]1[cH:4][cH:5][c:6]([CH:9]2[CH2:10][CH2:11][N:12]([CH2:32][CH2:31][CH2:30][n:24]3[c:23](=[O:34])[n:22]([CH2:15][c:16]4[cH:17][cH:18][cH:19][cH:20][cH:21]4)[cH:27][c:26]([CH3:28])[c:25]3=[O:29])[CH2:13][CH2:14]2)[cH:7][cH:8]1Participants
11
Reactant 10
Product 1
Sources & evidence
- ORD record
- ord-ff52c75d66dc4dbbb8ae88499b320b4e
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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