Potassium Cation → Ethyl 3-[2-fluoro-4-[[4-(spiro[indane-1,4'-piperidine]-1'-ylmethyl)phenyl]methoxy]phenyl]propanoate

HRID 122484Notes

Reaction equation

HRID 122484 reaction equation
[Br:1][CH2:2][c:3]1[cH:4][cH:5][c:6]([CH2:7][N:8]2[CH2:9][CH2:10][C:11]3([CH2:12][CH2:13][c:14]4[cH:15][cH:16][cH:17][cH:18][c:19]43)[CH2:20][CH2:21]2)[cH:22][cH:23]1.[F:24][c:25]1[c:26]([CH2:32][CH2:33][C:34](=[O:35])[O:36][CH2:37][CH3:38])[cH:27][cH:28][c:29]([OH:31])[cH:30]1.[K+:39].[K+:40].[O-:41][C:42]([O-:43])=[O:44].[O:45]=[CH:46][N:47]([CH3:48])[CH3:49].[OH2:50]>>[CH2:2]([c:3]1[cH:4][cH:5][c:6]([CH2:7][N:8]2[CH2:9][CH2:10][C:11]3([CH2:12][CH2:13][c:14]4[cH:15][cH:16][cH:17][cH:18][c:19]43)[CH2:20][CH2:21]2)[cH:22][cH:23]1)[O:31][c:29]1[cH:28][cH:27][c:26]([CH2:32][CH2:33][C:34](=[O:35])[O:36][CH2:37][CH3:38])[c:25]([F:24])[cH:30]1

Participants

7

Reactant 6

HCID 813Potassium Cation2×HCID 962WaterHCID 6228DimethylformamideHCID 19660Carbonate IonHCID 23082888Ethyl 3-(2-fluoro-4-hydroxyphenyl)propanoateHCID 670872261'-[4-(Bromomethyl)benzyl]-2,3-dihydrospiro[indene-1,4'-piperidine]

Product 1

HCID 67086942Ethyl 3-[2-fluoro-4-[[4-(spiro[indane-1,4'-piperidine]-1'-ylmethyl)phenyl]methoxy]phenyl]propanoate

Sources & evidence

ORD record
ord-a24fb70edcfb4471b7fa6c9c634d8be7
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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