Dimethyl Sulfoxide → Azemiglitazone

HRID 1224914Notes

Reaction equation

HRID 1224914 reaction equation
[CH3:27][S:28]([CH3:29])=[O:30].[CH3:31][CH2:32][N:33]([CH2:34][CH3:35])[CH2:36][CH3:37].[Cl:39][CH2:40][Cl:41].[OH2:38].[OH:1][CH:2]([CH2:3][O:4][c:5]1[cH:6][cH:7][c:8]([CH2:9][CH:10]2[C:11](=[O:16])[NH:12][C:13](=[O:15])[S:14]2)[cH:17][cH:18]1)[c:19]1[cH:20][c:21]([O:25][CH3:26])[cH:22][cH:23][cH:24]1>>[O:1]=[C:2]([CH2:3][O:4][c:5]1[cH:6][cH:7][c:8]([CH2:9][CH:10]2[C:11](=[O:16])[NH:12][C:13](=[O:15])[S:14]2)[cH:17][cH:18]1)[c:19]1[cH:20][c:21]([O:25][CH3:26])[cH:22][cH:23][cH:24]1

Participants

6

Reactant 5

HCID 679Dimethyl SulfoxideHCID 962WaterHCID 6344DichloromethaneHCID 8471TriethylamineHCID 469110405-{4-[2-Hydroxy-2-(3-methoxyphenyl)ethoxy]benzyl}-1,3-thiazolidine-2,4-dione

Product 1

HCID 25230266Azemiglitazone

Sources & evidence

ORD record
ord-09c4e970cecb4d7fa63ca77aeda54095
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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