Dimethylformamide → Methyl 6-(3-chloro-4-fluorobenzyl)-4-methoxy-2-methyl-3,5-dioxo-2,3,5,6,7,8-hexahydro-2,6-naphthyridine-1-carboxylate

HRID 1225149Notes

Reaction equation

HRID 1225149 reaction equation
[C:28](=[O:29])([O-:30])[O-:31].[Cl:1][c:2]1[cH:3][c:4]([CH2:5][N:6]2[C:7](=[O:23])[c:8]3[c:9]([OH:22])[c:10](=[O:21])[n:11]([CH3:20])[c:12]([C:16](=[O:17])[O:18][CH3:19])[c:13]3[CH2:14][CH2:15]2)[cH:24][cH:25][c:26]1[F:27].[Cs+:32].[Cs+:33].[I:34][CH3:35].[O:36]=[CH:37][N:38]([CH3:39])[CH3:40]>>[Cl:1][c:2]1[cH:3][c:4]([CH2:5][N:6]2[C:7](=[O:23])[c:8]3[c:9]([O:22][CH3:28])[c:10](=[O:21])[n:11]([CH3:20])[c:12]([C:16](=[O:17])[O:18][CH3:19])[c:13]3[CH2:14][CH2:15]2)[cH:24][cH:25][c:26]1[F:27]

Participants

6

Reactant 5

HCID 6228DimethylformamideHCID 6328Methyl iodideHCID 19660Carbonate IonHCID 104967Cesium cation2×HCID 69058481HCID 69058481, compound

Product 1

HCID 69058384Methyl 6-(3-chloro-4-fluorobenzyl)-4-methoxy-2-methyl-3,5-dioxo-2,3,5,6,7,8-hexahydro-2,6-naphthyridine-1-carboxylate

Sources & evidence

ORD record
ord-c1d9a4982edf4e67b410c03788acd836
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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