Methanol → (4-Methoxy-3-(methylsulfonyl)phenyl)(spiro[benzo[b]pyrrolo[1,2-d][1,4]oxazine-4,4'-piperidine]-1'-yl)methanone

HRID 1226019Notes

Reaction equation

HRID 1226019 reaction equation
[CH3:32][OH:33].[F:1][c:2]1[c:3]([S:28](=[O:29])(=[O:30])[CH3:31])[cH:4][c:5]([C:8](=[O:9])[N:10]2[CH2:11][CH2:12][C:13]3([CH2:14][CH2:15]2)[O:16][c:17]2[c:18]([cH:24][cH:25][cH:26][cH:27]2)-[n:19]2[c:20]3[cH:21][cH:22][cH:23]2)[cH:6][cH:7]1.[H-:35].[Na+:34].[O:36]=[CH:37][N:38]([CH3:39])[CH3:40]>>[c:2]1([O:33][CH3:32])[c:3]([S:28](=[O:29])(=[O:30])[CH3:31])[cH:4][c:5]([C:8](=[O:9])[N:10]2[CH2:11][CH2:12][C:13]3([CH2:14][CH2:15]2)[O:16][c:17]2[c:18]([cH:24][cH:25][cH:26][cH:27]2)-[n:19]2[c:20]3[cH:21][cH:22][cH:23]2)[cH:6][cH:7]1

Participants

6

Reactant 5

HCID 887MethanolHCID 923Sodium ionHCID 6228DimethylformamideHCID 166653HydrideHCID 58551140(4-Fluoro-3-methylsulfonyl-phenyl)-spiro[piperidine-4,4'-pyrrolo[2,1-c][1,4]benzoxazine]-1-yl-methanone

Product 1

HCID 58551251(4-Methoxy-3-(methylsulfonyl)phenyl)(spiro[benzo[b]pyrrolo[1,2-d][1,4]oxazine-4,4'-piperidine]-1'-yl)methanone

Sources & evidence

ORD record
ord-bff99ba63f0241e0a1a3d869b832c632
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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